1. Kaguya Ōtsutsuki: Kaguya Ōtsutsuki is the ultimate boss and the most powerful female character in Naruto. She is known as the progenitor of chakra and the incarnation of the Ten-Tails, possessing god-like abilities.
2. Konan: She possesses incredible origami ninjutsu abilities, including her 600 billion explosive tags technique. After the death of Nagato, she leaves the Akatsuki and meets her end in the Fourth Great Ninja War without being resurrected.
3. Hidan: Despite his unique powers, Hidan is ultimately defeated and buried alive by Shikamaru.
4. Zabuza Momochi: Zabuza Momochi is one of the first major villains in Naruto. He is a skilled swordsman and strategist, known as the Demon of the Hidden Mist.
5. Orochimaru: Orochimaru is one of the primary antagonists in Naruto and a former member of the Akatsuki. He is a master of forbidden jutsu and seeks immortality.