1. Naruto: Originally a "loser," Naruto eventually becomes the seventh Hokage. As a jinchuriki of the Nine-Tails, he can fully control the beast and use the Nine-Tails Chakra Mode. He gains recognition from the Great Toad Sage and the Six Paths Sage, allowing him to access the Six Paths Sage Mode and be on par with the Six Paths themselves. 

2. Sasuke: A genius shinobi of the Uchiha clan and the reincarnation of Indra. He possesses the Mangekyo Sharingan and activates the Rinnegan, inheriting the power of the Six Paths. With his six tomoe Rinnegan, Sasuke surpasses his ancestors and can outmatch nine tailed beasts, making him evenly matched with Naruto in his Six Paths Mode.

3. Obito Uchiha: Becomes the Ten-Tails Jinchuriki, wielding the Sage's staff and chakra receivers. He even overpowers the First Hokage. Naruto and Sasuke team up to defeat him, but his perfect Six Paths Mode proves to be a challenge. 

4. Kaguya Otsutsuki: Possesses the combined power of Yin and Yang from the Six Paths. As the true incarnation of the Six Paths, she is nearly unstoppable. However, she is eventually defeated when she awakens as the Ten-Tails Jinchuriki and is consumed by her own creation, the Infinite Tsukuyomi.